Speakers

Andrea Rau

Research Director at the French National Institute for Research in Agriculture, Food, and the Environment (INRAE).

Talk will be about data integration. Summary currently being written.

Etienne Becht

Researcher at the Center for Inflammation Research (CRI).

Talk will be about data deconvolution. Summary currently being written.

Fatima Al-Shahrour

Head of the Bioinformatics Unit at Spanish National Cancer Research Centre (CNIO).

Bioinformatics strategies to target cancer genomes considering inter and intratumor heterogeneity

Tumor heterogeneity presents significant obstacles in cancer treatment, often leading to treatment failure, drug resistance, and unfavorable patient outcomes. Precision oncology seeks to address these challenges by developing personalized treatment strategies through comprehensive data integration.

Single-cell RNA-seq technology has the transformative capabilities to unravel tumor heterogeneity at transcriptional level. This technology enables the high-resolution characterization of cellular composition, dynamics, and the identification of distinct cancer cell subpopulations, biomarkers, drug resistance pathways, and therapeutic targets. However, the integration of scRNA-seq data and drug response profiles lacks robust computational methodologies.